help genhwcci
                                                                (STB-57: sg150)
                                                              also see:  genhwi
-------------------------------------------------------------------------------

Title

    genhwcci --   Hardy-Weinberg equilibrium test in case-control studies


Syntax

        genhwcci #AA1 #Aa1 #aa1 #AA2 #Aa2 #aa2 [, options]


    options                Description
    -------------------------------------------------------------------------
    Main
      label(genotypes)     requests that labels are used in the output of the
                             genotype frequency table
      binvar               requests that the standard errors from a binomial
                             distribution are reported for each allele
                             frequency
    -------------------------------------------------------------------------


Description

    genhwcci is an immediate command used for estimating allele frequency,
    genotype frequencies, disequilibrium coefficients and the associated
    standard error for codominant traits or data of completely known
    genotypes in case-control studies.  For both genotypic counts of cases
    and controls, it performs asymptotic Hardy-Weinberg Equilibrium (HWE)
    tests. It also tests the HWE for genotypic counts of cases, under the
    assumption that the genotypic counts of controls are under HWE; where
    #AA1, #Aa1 and #aa1 are genotypic counts for the AA, Aa and aa of cases;
    while #AA2, #Aa2 and #aa2 are genotypic counts of the controls. This
    command works for biallelic loci only.


Options

        +------+
    ----+ Main +-------------------------------------------------------------

    label(genotypes)) requests that labels are used in the output of the
        genotype frequency table.

    binvar requests that the standard errors from a binomial distribution are
        reported for each allele frequency, under the assumption that the
        population is under HWE.  By default, standard errors without this
        assumption are calculated and reported.


Examples

    genhwcci 67 156 146 31 135 118, binvar label(AA Aa aa)

    genhwcci 41 47 21 37 58 18


Also see

    STB:  STB-48 sg110, STB-57 sg150

    Online:  genhwi


References

    Cui J. Hardy-Weinberg equilibrium test in case-control studies. Stata
        Technical Bulletin 2000; 57: 17-19.

    Cleves M. Hardy-Weinberg equilibrium test and allele frequency
        estimation. Stata Technical Bulletin 1999; 48: 34-37.


Author

    James Cui, Department of Epidemiology and Preventive Medicine, Monash
    University.

    Email: james.cui@med.monash.edu.au



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