{smcl}
{* *! version 1.0 14 Jul 2020}{...}
{vieweralsosee "" "--"}{...}
{vieweralsosee "Install command2" "ssc install command2"}{...}
{vieweralsosee "Help command2 (if installed)" "help command2"}{...}
{viewerjumpto "Syntax" "mtpi##syntax"}{...}
{viewerjumpto "Description" "mtpi##description"}{...}
{viewerjumpto "Options" "mtpi##options"}{...}
{viewerjumpto "Remarks" "mtpi##remarks"}{...}
{viewerjumpto "Examples" "mtpi##examples"}{...}
{title:Title}
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{bf:mtpi} {hline 2} A command for the modified Toxicity Probability Interval design
{marker syntax}{...}
{title:Syntax}
{p 8 17 2}
{cmdab:mtpi}
[{help varlist}]
[{cmd:,}
{it:options}]
{synoptset 20 tabbed}{...}
{synopthdr}
{synoptline}
{syntab:Optional}
{synopt:{opt ep1(#)}} specifies the lower bound of the interval around the TTL that is safe.
{pstd}
{p_end}
{synopt:{opt ep2(#)}} specifies the upper bound of the interval around the TTL that is safe.
{pstd}
{p_end}
{synopt:{opt safe1(#)}} specifies the safety cutoff for declaring the lowest dose to be safe.
{pstd}
{p_end}
{synopt:{opt safe2(#)}} specifies the safety cutoff for declating the dose to be safe.
{pstd}
{p_end}
{synopt:{opt ttl(#)}} specifies the target toxicity level that defines the maximum tolerated dose.
{pstd}
{p_end}
{synopt:{opt simn(#)}} specifes the number of simulations used
{pstd}
{p_end}
{synopt:{opt sampsize(#)}} specifies the sample size of each trial in the simulations.
{pstd}
{p_end}
{synopt:{opt csize(#)}} specifies the cohort size used in the trial.
{pstd}
{p_end}
{synopt:{opt startdose(#)}} specifies the starting dose.
{pstd}
{p_end}
{synopt:{opt priora(#)}} specifies the a parameter of the prior Beta distribution.
{pstd}
{p_end}
{synopt:{opt priorb(#)}} specifies the a parameter of the prior Beta distribution.
{pstd}
{p_end}
{synopt:{opt truep(numlist ascending >=0 <=1)}} specifies a vector of true probabilities of DLT for each dose level.
{pstd}
{p_end}
{synopt:{opt decisiontable}} specifies that the single cohort decision rules be displayed as a lookup table.
{pstd}
{p_end}
{synoptline}
{p2colreset}{...}
{p 4 6 2}
{marker description}{...}
{title:Description}
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{pstd}
The modified Toxicity Probability Interval design is an attempt to implement a method
that is as simple as a 3+3 decision but based on statistical distributions rather
than a pure rule-based approach. This method produces decision making tables for the fully
trial so a statistician need not be involved in all the dose escalation decisions.
{pstd}
The command {cmd:mtpi} performs simulations to find the operating characteristics alongside
the decision matrix given a sample size and number of DLTs.
{marker options}{...}
{title:Options}
{dlgtab:Main}
{phang}
{opt ep1(#)} specifies the lower bound of the interval around the TTL that is safe.
{pstd}
{p_end}
{phang}
{opt ep2(#)} specifies the upper bound of the interval around the TTL that is safe.
{pstd}
{p_end}
{phang}
{opt safe1(#)} specifies the safety cutoff for declaring the lowest dose to be safe.
{pstd}
{p_end}
{phang}
{opt safe2(#)} specifies the safety cutoff for declating the dose to be safe.
{pstd}
{p_end}
{phang}
{opt ttl(#)} specifies the target toxicity level that defines the maximum tolerated dose.
{pstd}
{p_end}
{phang}
{opt simn(#)} specifes the number of simulations used
{pstd}
{p_end}
{phang}
{opt sampsize(#)} specifies the sample size of each trial in the simulations.
{pstd}
{p_end}
{phang}
{opt csize(#)} specifies the cohort size used in the trial.
{pstd}
{p_end}
{phang}
{opt startdose(#)} specifies the starting dose.
{pstd}
{p_end}
{phang}
{opt priora(#)} specifies the a parameter of the prior Beta distribution.
{pstd}
{p_end}
{phang}
{opt priorb(#)} specifies the a parameter of the prior Beta distribution.
{pstd}
{p_end}
{phang}
{opt truep(numlist ascending >=0 <=1)} specifies a vector of true probabilities of DLT for each dose level.
{pstd}
{p_end}
{phang}
{opt decisiontable} specifies that the single cohort decision rules be displayed as a lookup table.
{pstd}
{p_end}
{marker examples}{...}
{title:Examples}
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The basic command will do a simulation
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{stata mtpi}
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The results show a table of each dose level with the true probabilities of a DLTs
and the proportion of time those doses are recommended, experimented
on and how many DLTs were observed on average.
{title:References}
{pstd}
{pstd}
Yuan Ji, Ping Liu, Yisheng Li and NB Bekele (2010) A modified toxicity probability
interval method for dose-finding trials. Clin. Trials 7(6) 653-663.
{title:Author}
{p}
Prof Adrian Mander, Cardiff University.
Email {browse "mailto:mandera@cardiff.ac.uk":mandera@cardiff.ac.uk}
{title:See Also}
Related commands:
{help crm} (if installed) {stata ssc install crm} (to install this command)