{smcl}
{hline}
help for {hi:sampsi_mcc}
{hline}

{title:Calculates Sample Size or Power for Matched Case-Control Studies}

{p 8 22}
{cmdab:sampsi_mcc}
[,
{opt p0(#)}
{opt alt(#)}
{opt n1(#)}
{opt m(#)}
{opt phi(#)}
{opt a:lpha(#)}
{opt power(#)}
{opt s:olve(string)}
}
]

{p}

{title:Description}

{p 0 0}
{hi: sampsi_mcc} calculates the power and sample size for a matched case control study. The theory behind this
command is described in Dupont (1988) Power Calculations for Matched Case-Control Studies, Biometrics.

{p 0 0}
The calculations require the usual alpha and beta values, a possible alternative odds ratio (the null is 1), phi the
correlation of exposure between pairs in the case-control set (the default is 0.2) and the probability of exposure in
the controls.

{p 0 0}
This command can be combined with {hi:samplesize} in order to look at multiple calculations and to plot the results.

{title:Updating this command}

{p 0 0}
To obtain the latest version click the following to uninstall the old version
{p_end}
{stata ssc uninstall sampsi_mcc}
And click here to install the new version
{stata ssc install sampsi_mcc}

{title:Options}

{p 0 0}
{opt p0(#)} specifies the exposure probability of controls; default is {hi:p0(0.5)}.

{p 0 0}
{opt alt(#)} specifies the "alternative OR".

{p 0 0}
{opt n1(#)} specifies the number of cases; default is {hi:n1(100)}.

{p 0 0}
{opt m(#)} specifies the number of matched controls per case; default is {hi:m(1)}.

{p 0 0}
{opt a:lpha(#)} significance level of test; default is {hi:a(0.05)}.

{p 0 0}
{opt power(#)} power of test; default is {hi:p(0.9)}.

{p 0 0}
{opt s:olve(string)} specifies whether to solve for the sample size or power; default is {hi:s(n)} solves for n and
the only other choice is {hi:s(power)} solves for power.

{p 0 0}
{opt phi(#)} specifies the correlation of exposure between pairs in the case-control set. The paper recommends the
default value {hi:0.2} when it is unknown.

{title:Examples}

{p 0 0}
Calculate power for a two-sided test:
{p_end}

{p 2 2}
{stata sampsi_mcc, p0(0.5) alt(1.5) n(100) s(power)}

{p 0 0}
Compute sample size:

{p 2 2}
{stata sampsi_mcc, p0(0.5) alt(1.5) s(n)}

{p 0 0}
Compute sample size when the power is 80%:

{p 2 2}
{stata sampsi_mcc, p0(0.5) alt(1.5) s(n) power(0.8)}

{p 0 0}
Re-calculate the above values for 5 matched controls rather than 1:
{p_end}

{p 2 2}
{stata sampsi_mcc, p0(0.5) alt(1.5) n(100) s(power) m(5)}

{p 0 0}
Compute sample size:

{p 2 2}
{stata sampsi_mcc, p0(0.5) alt(1.5) s(n) m(5)}

{title:Author}

{p}
Adrian Mander, MRC Human Nutrition Research, Cambridge, UK.

Email {browse "mailto:adrian.mander@mrc-hnr.cam.ac.uk":adrian.mander@mrc-hnr.cam.ac.uk}

{title:Reference}

Dupont W.D. (1988) Power calculations for matched case-control studies. Biometrics 44: 1157-1168.
 
{title:See Also}
Related commands:

{p 2 2}
{help sampsi}, {help samplesize} (if installed), {help sampclus} (if installed), {help xsampsi} (if installed), {help artmenu} (if installed)