*! version 1.0 14 May 2018

Title

des_gehan -- Design a two-stage Gehan single-arm trial for a single binary endpoint

Syntax

des_gehan
[,
options]

Main
pi1(#) The (desirable) response probability. Defaults to 0.3.

beta1(#) The desired maximal type-II error-rate for stage one. Defaults to 0.1.

gamma(#) The desired standard error for the estimate of the response probability by the end of stage two. Defaults to 0.05.

alpha(#) The confidence level to use in the formula for computing the second stage sample sizes. Defaults to 0.05.

summary(#) An integer indicating whether a summary of the function's progress should be printed (summary = 1) to the console. Defaults to 0.

plot Indicates that a plot of the second stage sample sizes should be produced.

* Additional options to use during plotting.

Description

Supports the determination of two-stage Gehan single-arm clinical trial designs
for a single binary primary endpoint.

Options

Main

pi1(#) The (desirable) response probability. Defaults to 0.3.

beta1(#) The desired maximal type-II error-rate for stage one. Defaults to 0.1.

gamma(#) The desired standard error for the estimate of the response probability by the end of stage two. Defaults to 0.05.

alpha(#) The confidence level to use in the formula for computing the second stage sample sizes. Defaults to 0.05.

summary(#) An integer indicating whether a summary of the function's progress should be printed (summary = 1) to the console. Defaults to 0.

plot Indicates that a plot of the second stage sample sizes should be produced.

* Additional options to use during plotting.

Examples

des_gehan

des_gehan, beta1(0.2) plot

Author

Michael J. Grayling, MRC Biostatistics Unit, Cambridge.

Email mjg211@cam.ac.uk