{smcl}
{* *! version 1.0  16 Apr 2015}{...}
{vieweralsosee "" "--"}{...}
{vieweralsosee "Install command2" "ssc install command2"}{...}
{vieweralsosee "Help command2 (if installed)" "help command2"}{...}
{viewerjumpto "Syntax" ÒhaybittlePeto##syntax"}{...}
{viewerjumpto "Description" "haybittlePeto##description"}{...}
{viewerjumpto "Options" "haybittlePeto##options"}{...}
{viewerjumpto "Remarks" "haybittlePeto##remarks"}{...}
{viewerjumpto "Examples" "haybittlePeto##examples"}{...}
{title:Title}
{phang}
{bf:haybittlePeto} {hline 2} Group Sequential Design with Haybittle-Peto Boundaries

{marker syntax}{...}
{title:Syntax}
{p 8 17 2}
{cmdab:haybittlePeto}
[{cmd:,}
{it:options}]

{synoptset 20 tabbed}{...}
{synopthdr}
{synoptline}
{syntab:Main}
{synopt:{opt l(integer 3)}} The maximum number of allowed stages in the design. Must be an integer greater than or equal to 2.{p_end}
{synopt:{opt d:elta(real 0.2)}} The clinically relevant difference at which to power. Must be strictly positive.{p_end}
{synopt:{opt a:lpha(real 0.05)}} The desired type-I error rate. Must be strictly between 0 and 1.{p_end}
{synopt:{opt b:eta(real 0.2)}} The desired type-II error rate. Must be strictly between 0 and 1.{p_end}
{synopt:{opt s:igma(numlist)}} The standard deviation of the responses in the two arms. This can either be of length two, containing the assumed values of these responses, or of length one, implying the standard deviation in each arm is equal. All values must be strictly positive.{p_end}
{synopt:{opt r:atio(real 1)}} The desired ratio of the sample sizes between the two arms. Must be strictly positive.{p_end}
{synopt:{opt per:formance}} Specifies that the performance of the identified design, i.e. its expected sample size and power curves, should be determined and plotted.{p_end}
{synopt:{opt *}} Additional options to pass to twoway.{p_end}
{synoptline}
{p2colreset}{...}
{p 4 6 2}

{marker description}{...}
{title:Description}
{pstd}
{cmd:haybittlePeto} determines the boundaries of, and sample size required by, a group sequential design with Haybittle-Peto boundaries.

{marker options}{...}
{title:Options}
{dlgtab:Main}
{phang}
{opt l(integer 3)} The maximum number of allowed stages in the design. Must be an integer greater than or equal to 2.

{phang}
{opt d:elta(real 0.2)} The maximum number of allowed stages in the design. Must be an integer greater than or equal to 2.

{phang}
{opt a:lpha(real 0.05)} The desired type-I error rate. Must be strictly between 0 and 1.

{phang}
{opt b:eta(real 0.2)} The desired type-II error rate. Must be strictly between 0 and 1.

{phang}
{opt s:igma(numlist)} The standard deviation of the responses in the two arms. This can either be of length two, containing the assumed values of these responses, or of length one, implying the standard deviation in each arm is equal. All values must be strictly positive.

{phang}
{opt r:atio(real 1)} The desired ratio of the sample sizes between the two arms. Must be strictly positive.

{phang}
{opt per:formance} Specifies that the performance of the identified design, i.e. its expected sample size and power curves, should be determined and plotted.

{phang}
{opt *} Additional options to pass to twoway.

{marker examples}{...}
{title:Examples}

{phang} 
{stata haybittlePeto, sigma(1)}

{phang} 
{stata haybittlePeto, l(2) delta(0.25) alpha(0.1) beta(0.1) sigma(2, 3) ratio(2) per}

{title:Authors}
{p}

Michael J. Grayling & Adrian P. Mander,
MRC Biostatistics Unit, Cambridge, UK.

Email {browse "mjg211@cam.ac.uk":mjg211@cam.ac.uk}

{title:See Also}

References:

Haybittle JL (1971) Repeated assessment of results in clinical trials of
cancer treatment. The British Journal of Radiology 44(526):793Ð797.

Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N,
McPherson K, Peto J, Smith PG (1976) Design and analysis of randomized
clinical trials requiring prolonged observation of each patient.
I. Introduction and design. British Journal of Cancer 34(6):585Ð612.
  
Related commands:

{help doubleTriangular} (if installed)
{help innerWedge} (if installed)
{help powerFamily} (if installed)
{help triangular} (if installed)
{help wangTsiatis} (if installed)