*! version 1.0 15 May 2018

Title

opchar_curtailed -- Determine the operating characteristics of group sequential single-arm trial designs for a single binary endpoint

Syntax

opchar_curtailed
[,
options]

Main
j(#) The maximal number of stages to allow. Defaults to 2.

pi1(#) The (desirable) response probability at which the trial is powered. Defaults to 0.3.

n(numlist) Numlist of stage-wise sample sizes. Internally defaults to 10,19.

a(numlist miss) Numlist of acceptance boundaries. Internally defaults to 1,5.

r(numlist miss) Numlist of rejection boundaries. Internally defaults to .,6.

thetaf(numlist) A numlist of futility curtailment probabilities. Internally defaults to 0,...,0.

thetae(numlist) A numlist of efficacy curtailment probabilities. Internally defaults to 1,...,1.

k(numlist) Calculations are performed conditional on the trial stopping in one of the stages listed in numlist k. Thus, k should be a numlist of integers, with elements between one and the maximum number of possible stages. If left unspecified, it will internally default to all possible stages.

pi(numlist) Numlist of response probabilities to evaluate the expected performance of the point estimation procedures at. This will internally default to 0,0.01,...,1.

summary(#) An integer indicating whether a summary of the function's progress should be printed (summary = 1) to the console. Defaults to 0.

plot Indicates whether a plot should be produced. If set to power then the power curve will be procedured. If set to ess then the ESS curve will be produced.

* Additional options to use during plotting.

Description

For each value of pi in the supplied numlist pi, opchar_curtailed evaluates the
power, ESS, and other key characteristics, of each of the supplied designs.

Options

Main

j(#) The maximal number of stages to allow. Defaults to 2.

n(numlist) Numlist of stage-wise sample sizes. Internally defaults to 10,19.

a(numlist miss) Numlist of acceptance boundaries. Internally defaults to 1,5.

r(numlist miss) Numlist of rejection boundaries. Internally defaults to .,6.

thetaf(numlist) A numlist of futility curtailment probabilities. Internally defaults to 0,...,0.

thetae(numlist) A numlist of efficacy curtailment probabilities. Internally defaults to 1,...,1.

k(numlist) Calculations are performed conditional on the trial stopping in one of the stages listed in numlist k. Thus, k should be a numlist of integers, with elements between one and the maximum number of possible stages. If left unspecified, it will internally default to all possible stages.

pi(numlist) Numlist of response probabilities to evaluate the expected performance of the point estimation procedures at. This will internally default to 0,0.01,...,1.

summary(#) An integer indicating whether a summary of the function's progress should be printed (summary = 1) to the console. Defaults to 0.

plot Indicates whether a plot should be produced. If set to bias that the bias curve will be procedured. If set to rmse then the RMSE curve will be produced.

* Additional options to use during plotting.

Examples

opchar_curtailed

opchar_curtailed, n(15, 10) a(1, 5) r(., 6)

Author

Michael J. Grayling, MRC Biostatistics Unit, Cambridge.

Email mjg211@cam.ac.uk

See Also

Related commands:

des_curtailed (if installed)